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Australia's sex-offender travel ban resulted in terrible side effect

In December last year, legislation was introduced to stop sex-offenders from travelling out of the country to places where they could abuse young children.

But numbers of pedophiles live streaming child pornography from Southeast Asia has gone through the roof, some paying as little as $50 to watch a child abused live online.

Senator Derryn Hinch was instrumental in bringing in the travel ban legislation.

"We are working on new cybersex laws to try and stop it."

He tells Ben he's faced backlash since introducing the ban, with people arguing it would drive up sexual abuse cases in Australia.

"I'm interested in trying to save the lives and innocence of children everywhere," he says.

"These were child-rape holidays. At least in Australia police are aware of people who are on the register.

"I can assure you we are working very hard on getting new laws in."

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Anticholinesterase activity of 7-methoxyflavones isolated from Kaempferia parviflora

The rhizome of Kaempferia parviflora or kra-chai-dum (in Thai) is used traditionally as a folk medicine. The preliminary cholinesterase inhibitory screening of this plant extract exhibited significant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. Thirteen known methoxyflavones (1–13) were isolated and their structures were completely elucidated based on NMR analysis and compared with literature reports. Minor compounds 12–13 were reported for the first time from this species. The cholinesterase inhibitory test results showed that the highest potential inhibitors toward AChE and BChE were 5,7,4'-trimethoxyflavone (6) and 5,7-dimethoxyflavone (7), respectively, with the percentage inhibitory activity varying over 43–85%. The structure-activity relationship study led to the conclusion that compounds bearing 5,7-dimethoxy groups and a free substituent at C-3 had a significant inhibitory effect at a concentration of 0.1 mg/mL, but those bearing a 5-hydroxyl group reduced the inhibitory potency. On the other hand, flavones bearing a 3'- or 5'-methoxy group did not influence the inhibitory effect. Interestingly, 5,7-dimethoxyflavone (7) exhibited strong selectivity for BChE over AChE which may be of great interest to modify as a treatment agent for Alzheimer's disease.

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