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Australian sex cult leader selling his 'holy grounds'

Convicted Australian cult leader William "Little Pebble" Kamm is selling the "sacred" property where he claims the Virgin Mary told him to repopulate the Earth with two 15-year-old girls.

Kamm, who now calls himself William Costellia, founded the Order of Saint Charbel on the New South Wales' south coast in the 1980s and preached a doomsday Christian message.

His followers handed over wives and daughters to help him rebuild humanity after the apocalypse and he has reportedly fathered more than 20 children.

He spent nine years in jail for having sex with two teenage girls before being paroled in November 2014.

On his website, which he actively updates with reams of legal documents and preachings, he announced he would "let the Holy Sacred Grounds go" after it hosted thousands of miracles, cures and conversions.

"I had to purchase the land to save and protect it, but now we are unable to continue with paying the mortgage, which was very high, due to the lack of support," he wrote on April 19.

He previously said his followers had chipped in to help make repayments after he was imprisoned in 2002 but that financial aid has since dried up.

"I wish to thank all our dear faithful followers who have been such a strong support over so many years, helping me maintain the mortgage payments and those who have worked so hard looking after the Holy Grounds," he said.

"It is God's property first and foremost - even if we should lose it."

Kamm is suing the NSW Government in the Supreme Court so he can return to Facebook and Twitter, he said on his website in March.

He blamed the "authorities and media", along with his extended detention orders, for forcing him to sell the property.

The self-proclaimed seer's high-profile lawyer Omar Juweinat said the sale was the "sad reality of long-term litigation".

"Unfortunately, given the frequency and complexity of Mr Kamm's matters currently before the court, it has meant that he has been compelled to dispose of an asset," he said.

The 2.44 hectare bush property, located 10 kilometres from Nowra, is dotted with religious structures including shrines, a holy water spring, Stations of the Cross, a large work shed and a burned-out house.

Kamm wants A$800,000 for the property.

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Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function

The purpose of this study was to examine the effects of extracts and flavone derivatives from the rhizome of Kaempferia parviflora on P-glycoprotein (P-gp)-mediated transport in LLC-GA5-COL150, a transfectant cell line of a porcine kidney epithelial cell line LLC-PK1 with human MDR1 cDNA. Ethanol extract obtained from Kaempferia parviflora rhizome significantly increased the accumulation of rhodamine 123 and daunorubicin, P-gp substrates, in LLC-GA5-COL150 cells, but not in LLC-PK1 cells. The aqueous extract also increased the accumulation in LLC-GA5-COL150 cells with lower potency than the ethanol extract. The effects of flavone derivatives isolated from the rhizome of Kaempferia parviflora on P-gp function were examined. Among six flavones tested, 3,5,7,3',4'-pentamethoxyflavone most potently increased the accumulation of rhodamine 123 and daunorubicin in LLC-GA5-COL150 cells in a concentration-dependent manner. In addition, 5,7-dimethoxyflavone to lesser degree increased rhodamine 123 accumulation in LLC-GA5-COL150 cells. In contrast, the other four flavone derivatives had no significant effect on the accumulation of rhodamine 123 in LLC-GA5-COL150 cells in a concentration range tested. These results indicate that extracts and flavone derivatives from the rhizome of Kaempferia parviflora can inhibit P-gp function, which may be useful for overcoming P-gp-mediated multidrug resistance and improving the oral bioavailability of anticancer agents.

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